Endeavor Provides Long-Term Reassurance

Healing First. Results that Last.

• In ENDEAVOR III at 5 years, Endeavor DES shows a significant 37% relative risk reduction vs. Cypher DES in MACE (Endeavor DES 14.0% vs. Cypher DES 22.2%, p = 0.0495)¹⁰
• Primary endpoint in ENDEAVOR III: In-segment late lumen loss by QCA at 8 months, 0.36 for Endeavor DES vs. 0.13 for Cypher DES (p<0.001)
• In the ZEST study², at 2 years, Endeavor DES is superior to Taxus DES and non-inferior to Cypher DES in the composite primary endpoint of Death, MI and ischemia-driven TVR (Endeavor 11.3% and Taxus 15.2% p=0.014, Endeavor 11.3% and Cypher 9.9% p=0.43)
• 18% Observed Relative Risk Reduction in TVF at 5 years in ENDEAVOR IV

Durable Efficacy

• Evidence of Late TLR Catch-Up in ENDEAVOR IV with Taxus DES Leads to Similar TLR Rates at 5 Years (Endeavor DES 7.7% vs Taxus DES 8.6%, p=0.70)
• In ENDEAVOR III, 86% increase in TLR with Cypher DES vs. 21% increase with Endeavor DES from years 1–5 drives similar TLR rate at 5 years (Endeavor DES 8.0% vs. Cypher DES 6.5%, p = 0.547)⁹
• Only 0.3% increase in TLR between years 3 & 5 in ENDEAVOR II³

Reassuring Long-Term Safety

• E-Five Registry⁴ 2-year follow-up in over 2000 real-world patients⁴, many with complex attributes (11.4% AMI, 30.1% diabetic), showed very low 5.1% TLR and 0.7% ARC Def/Prob. ST to 2 years (0.1% ARC Def./Prob. VLST). These results are consistent with ENDEAVOR Pooled Analysis (Pre-Approval RCT trials)
• Significant Reduction in CD/MI vs. BMS at 5 Years in Pooled Analysis (Endeavor DES 5.7 % vs. BMS 8.4%, p = 0.016)¹
• 78% Significant Relative Risk Reduction in Very Late Stent Thrombosis in ENDEAVOR IV at 5 years (Endeavor DES 0.4% vs Taxus DES 1.8%, p=0.012)
• In ENDEAVOR III at 5 years¹², Endeavor DES shows 80% relative risk reduction in CD/MI (Endeavor DES 1.3% vs. Cypher DES 6.5%, p = 0.003)⁹
• Rapid, complete and functional healing.^5,6

Excellent Deliverability

• Proven Driver stent platform and low periprocedure/NQWMI⁷

Consistent Results Across Comprehensive and Robust Clinical Program

• TLR rates and safety outcomes among real-world patients consistent with Endeavor pooled analysis⁸
• Similar efficacy across multiple randomised clinical trials
• More than 1,000 Endeavor patients in trial program¹
• More than 2,000 patients studied to 5 years¹

¹ ENDEAVOR Pooled 5 year: EI (5 year); EII (5 year); EII CA (4 year); EIII (5 year); EIV (5 year); E pk (5 year)
² Park S, et al., TCT AP 2010.
³ ENDEAVOR II 5 year Kandzari, PCR 2009
⁴ E-Five Registry n=2116 prespecified subset, ACC 09
⁵ 100% of Endeavor struts covered by 6 months in OCT. Guagliumi et al., ESC 2008.
⁶ Haraguchi et al. TCT 2006
⁷ ENDEAVOR IV 5 year. p-Values for outcome differences are unadjusted for multiple comparisons.
⁸ Rothman et al. TCT 2008
⁹ p-Value was calculated by Fisher Exact test.
¹⁰ p-Value was calculated by logrank test. p-Values are unadjusted for multiple comparisons.
¹¹ ENDEAVOR IV was not specifically designed or powered to individually compare VLST, CD/MI, or TLR
¹² ENDEAVOR III was not specifically designed or powered to individually compare CD/MI, MACE, or TLR.
MACE is composed of Death, MI, Emergent CABG, TLR.
ENDEAVOR Pooled Analysis: E I 5-year, E II 5-year, E II CA 5-year, E III 5-year, E IV 3-year, E pK 3-year.
ARC definite/probable stent thrombosis definition used.
p-Values are unadjusted for multiple comparisons.